Great protection for my iPhone. I carry this on long hikes on weekends and to construction sites during the week. While Otterbox makes it clear the Defender case is not waterproof, it does provide some degree of moisture barrier. I carry this around in my backpack which sometimes gets rained on for hours at a time.
The touch-screen cover works well but the loss of sensitivity is most noticeable in the far corners of the screen.
It's not that easy to get the iPhone in and out of the case--the price to pay for that degree of protection--so seems made to stay on the phone all the time rather than taken on and off as needed. I feel frequently taking the phone in and out of the case will cause parts of the case to break or tear.
Pros: High quality, Durable, looks good
Cons: loss of touch-screen sensitivity in far corners, tricky to take off and on