I haven't tried to charge this in a cradle but based on other experiences with Otterboxes and iPhones, they never fit into cradles with the Otterbox Defender cases on the phones. The case adds a lot of girth and weight to the phone - but worth the trade-off for protection provided by the Otterbox Defender cases.
I plug my phone into charging cables vs. cradles - this is no problem to do. There is a small rubber that pulls down and exposes the charging port.
9 months ago